Following oral administration, plasma concentrations of unchanged buspirone are very low and variable between subjects. In a radiolabeled study, unchanged buspirone in the plasma accounted for only about 1% of the radioactivity in the plasma. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.īuspirone hydrochloride tablets are rapidly absorbed in man and undergo extensive first-pass metabolism. In vivo when tested in preclinical models.īuspirone has moderate affinity for brain DĢ-dopamine receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HTġA) receptors. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. The mechanism of action of buspirone is unknown.
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